[巴西副球孢子菌一种纯化抗原与副球孢子菌病和组织胞浆菌病血清的反应性]
[Reactivity of a purified antigen of Paracoccidioides brasiliensis with paracoccidioidomycosis and histoplasmosis sera].
作者信息
Torres J M, Da Luz S, Lopez-Lemes M H, Guisantes J, Josef M, Nieto A, Coch J, Yarzabal L A
出版信息
Ann Parasitol Hum Comp. 1975 Jul-Aug;50(4):507-13.
The immunoelectrophoretic reactivity of a "crude" and a "purified" antigens of Paracoccidiodes brasiliensis against the sera of confirmed cases of paracoccidioidomycosis and histoplasmosis was evaluated. The "crude" antigen revealed precipitating antibodies in both the homologous and the heterologous human sera; the number of precipitating systems being higher with the former. The "purified" antigen reacted only with the homologous sera. It is postulated that the use of such "purified" antigen may significantly reduce the non specificity of the serologic tests in the immunodiagnosis of paracoccidioidomycosis.
对巴西副球孢子菌的“粗制”和“纯化”抗原针对副球孢子菌病和组织胞浆菌病确诊病例血清的免疫电泳反应性进行了评估。“粗制”抗原在同源和异源人血清中均显示出沉淀抗体；前者的沉淀系统数量更多。“纯化”抗原仅与同源血清发生反应。据推测，使用这种“纯化”抗原可能会显著降低副球孢子菌病免疫诊断中血清学检测的非特异性。
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