Gruber H E, Osborne J W
Lab Anim. 1979 Jul;13(3):199-202. doi: 10.1258/002367779780937717.
An alteration in the host response to the intestinal protozoan Spironucleus (Hexamita) muris was noted in x-irradiated rat small intestine. When few were present in the crypt lumina, the intestinal microvillar border was normal. However, when larger numbers were present, the microvilli were greatly reduced in numbers or entirely absent in some regions. The organism was identified in the base of the crypt lumen, in apical portions of mucous cells, and near the basement membrane. Spironucleus enclosed by digestive vacuoles occasionally appeared to be in the process of being extruded through the basement membrane. Not all intracellular protozoa were surrounded by such digestive vacuoles. Spironucleus was never seen in association with the digestive vacuoles of Paneth cells. Since it has been suggested that Paneth cells have a role as a fixed phagocyte, ingesting protozoa and other microorganisms, the results presented here suggest that this function may have been impaired in irradiated animals.
在接受x射线照射的大鼠小肠中，观察到宿主对肠道原生动物鼠螺旋体（六鞭毛虫）的反应发生了改变。当隐窝腔中数量较少时，肠道微绒毛边界正常。然而，当数量较多时，微绒毛数量大大减少，在某些区域甚至完全消失。该生物体在隐窝腔底部、黏液细胞顶端部分以及基底膜附近被发现。被消化液泡包围的螺旋体偶尔似乎正通过基底膜被挤出。并非所有细胞内原生动物都被这种消化液泡包围。从未观察到螺旋体与潘氏细胞的消化液泡相关联。由于有人提出潘氏细胞具有固定吞噬细胞的作用，可吞噬原生动物和其他微生物，因此这里呈现的结果表明，在受照射动物中这种功能可能已受损。
