IgM抗体在H-2激活的小鼠T淋巴细胞上的特异性吸附。
Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes.
作者信息
Hudson L, Sprent J
出版信息
J Exp Med. 1976 Feb 1;143(2):444-9. doi: 10.1084/jem.143.2.444.
Abstract
Evidence is presented to support the contention that IgM demonstrable by surface immunofluorescent staining on H-2-activated T cells represents specifically adsorbed B-cell-derived alloantibody. T cells activated to H-2 determinants expressed surface IgM only when the progenitor cell populations contained B lymphocytes. IgM was not detected on T cells activated to determinants which fail to stimulate alloantibody production (e.g., M-locus determinants). In addition, IgM-negative H-2 activated T cells (derived from B-cell-depleted lymphoid cells), unlike M-locus-activated T cells, adsorbed IgM in a specific manner when incubated in vitro with "early bleed" antisera raised against the activating H-2 determinants.
摘要
有证据支持这样的论点，即通过表面免疫荧光染色在H-2激活的T细胞上可检测到的IgM代表特异性吸附的B细胞来源的同种抗体。仅当祖细胞群体中含有B淋巴细胞时，被激活至H-2决定簇的T细胞才表达表面IgM。在被激活至不能刺激同种抗体产生的决定簇（例如M位点决定簇）的T细胞上未检测到IgM。此外，与M位点激活的T细胞不同，IgM阴性的H-2激活的T细胞（源自B细胞缺失的淋巴细胞）在体外与针对激活的H-2决定簇产生的“早期出血”抗血清一起孵育时，以特异性方式吸附IgM。
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