Q热期间豚鼠肝脏中的核糖核酸与蛋白质合成
Ribonucleic acid and protein synthesis in guinea pig liver during Q fever.
作者信息
Thompson H A, Paretsky D
出版信息
Infect Immun. 1973 May;7(5):718-24. doi: 10.1128/iai.7.5.718-724.1973.
Abstract
Protein and ribonucleic acid (RNA) syntheses increase in the liver during Q fever, coincident with progressive increments in cortisol levels. Cell-free protein-synthesizing systems indicate that the pH 5 enzyme fraction was chiefly responsible for enhanced activity. Although the polysome profiles from normal and infected livers were similar, the number of liver ribosomes doubled during infection. There was a concomitant increase in orotate incorporation in the 28s, 18s, and 4s RNA species of infected liver.
摘要
在Q热期间，肝脏中的蛋白质和核糖核酸（RNA）合成增加，这与皮质醇水平的逐渐升高同时发生。无细胞蛋白质合成系统表明，pH 5酶组分是活性增强的主要原因。尽管正常肝脏和受感染肝脏的多核糖体图谱相似，但感染期间肝脏核糖体的数量增加了一倍。受感染肝脏的28s、18s和4s RNA种类中的乳清酸掺入也随之增加。
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