Pegrum G D
Immunology. 1971 Jul;21(1):159-64.
Normal and leukaemic lymphocytes from healthy donors and patients with chronic lymphatic leukaemia exhibit increased DNA synthesis in `one way' cultures with foetal cells. Leukaemic blast cells do not react. Foetal thymocytes showed a marked response to both normal and leukaemic cells in mixed cultures. Leukaemic lymphocytes in particular caused a marked increase in [H]thymidine uptake, suggesting a wider antigenic disparity between the leukaemic and thymic cells. Lesser increases of DNA synthesis were produced in foetal liver cells and none in spleen cells.
来自健康供体和慢性淋巴细胞白血病患者的正常淋巴细胞和白血病淋巴细胞，在与胎儿细胞进行“单向”培养时，其DNA合成增加。白血病原始细胞无反应。在混合培养中，胎儿胸腺细胞对正常细胞和白血病细胞均表现出明显反应。特别是白血病淋巴细胞导致[H]胸腺嘧啶核苷摄取显著增加，这表明白血病细胞与胸腺细胞之间存在更大的抗原差异。胎儿肝细胞中DNA合成有较小增加，而脾细胞中则无增加。
