对二硝基氯苯接触性超敏反应中的免疫耐受。剂量和时间依赖性。可能的细胞动力学。
Immunological tolerance in contact-hypersensitivity to dinitrochlorobenzene. Dose and time dependence. Possible cellular kinetics.
作者信息
Frey J R, de Weck A L, Geleick H, Polak L
出版信息
Immunology. 1971 Sep;21(3):483-7.
By determining the time and dose dependence of immuno-tolerance to dinitrochlorobenzene (DNCB) induced in guinea-pigs by previously injecting dinitrobenzenesulphonate (DNBSO), it was found that smaller doses of DNBSO injected at short time intervals before the epicutaneous application of DNCB induced tolerance in fewer animals than higher doses. However, with small doses of DNBSO, the percentage of tolerant animals increased the longer the time intervals between both hapten applications. A working hypothesis for this unexpected finding is proposed.
通过测定先前注射二硝基苯磺酸盐（DNBSO）诱导豚鼠对二硝基氯苯（DNCB）免疫耐受的时间和剂量依赖性，发现与高剂量相比，在皮内应用DNCB之前短时间间隔注射较小剂量的DNBSO诱导耐受的动物较少。然而，对于小剂量的DNBSO，两次半抗原应用之间的时间间隔越长，耐受动物的百分比越高。针对这一意外发现提出了一个可行的假设。
Zotero 插件