两性霉素B微量测定法。
Microassay foramphotericin B.
作者信息
Bannatyne R M, Cheung R, Devlin H R
出版信息
Antimicrob Agents Chemother. 1977 Jan;11(1):44-6. doi: 10.1128/AAC.11.1.44.
Abstract
Depending on the hematocrit, duplicate or triplicate determinations of serum amphotericin B concentration may be made on as little as 100 mul of capillary blood obtained by finger prick. In an accurate plate diffusion bioassay, using Paecilomyces varioti as the indicator organism, levels of the drug in the therapeutic range can be determined fast enough for clinicians to modify their next dose.
摘要
根据血细胞比容，通过手指针刺采集仅100微升的毛细血管血，即可对血清两性霉素B浓度进行重复或三次测定。在精确的平板扩散生物测定中，以拟青霉作为指示生物，能够足够快速地测定治疗范围内的药物水平，以便临床医生调整下一次剂量。
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本文引用的文献
1
Bioassay for hamycin and amphotericin B in serum and other biological fluids.血清及其他生物体液中哈霉素和两性霉素B的生物测定法。
Appl Microbiol. 1969 Apr;17(4):497-503. doi: 10.1128/am.17.4.497-503.1969.
2
Amphotericin B serum concentrations during therapy.治疗期间两性霉素B的血清浓度。
Appl Microbiol. 1970 Jun;19(6):955-9. doi: 10.1128/am.19.6.955-959.1970.
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