在两性霉素B存在的情况下对5-氟胞嘧啶进行的简易检测
Simple assay for 5-fluorocytosine in the presence of amphotericin B.
作者信息
Kauffman C A, Carleton J A, Frame P T
出版信息
Antimicrob Agents Chemother. 1976 Mar;9(3):381-3. doi: 10.1128/AAC.9.3.381.
Abstract
A simple method for the measurement of 5-fluorocytosine in the presence of amphotericin B is described. The antifungal activity of amphotericin B is abolished by heating serum at 100 C for 45 min. 5-Fluorocytosine is unaffected by this treatment, and serum levels can be subsequently assayed by either tube dilution or disk diffusion methods.
摘要
描述了一种在两性霉素B存在下测定5-氟胞嘧啶的简单方法。通过将血清在100℃加热45分钟可消除两性霉素B的抗真菌活性。5-氟胞嘧啶不受该处理的影响，随后可通过试管稀释法或纸片扩散法测定血清水平。
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