γ-谷氨酰转肽酶。在强直性肌营养不良中活性升高。

Gamma-glutamyl transpeptidase. Elevated activity in myotonic dystrophy.

作者信息

Alevizos B, Spengos M, Vassilopoulos D, Stefanis C

出版信息

J Neurol Sci. 1976 Jun;28(2):225-31. doi: 10.1016/0022-510x(76)90105-2.

Abstract

gamma-Glutamyl transpeptidase, a membrane-bound enzyme playing an important role in the active amino acid transport across cellular membranes, is shown to be elevated in the serum of patients with myotonic muscular dystrophy. No increase of AP, LAP, GOT and GPT activities in the sera of some of the patients studied is observed. Possible interpretations in relation to the pathogenesis of myotonic dystrophy are discussed.

摘要

γ-谷氨酰转肽酶是一种膜结合酶，在活性氨基酸跨细胞膜转运中起重要作用，已证实在强直性肌营养不良患者的血清中该酶水平升高。在所研究的部分患者血清中未观察到碱性磷酸酶（AP）、亮氨酸氨基肽酶（LAP）、谷草转氨酶（GOT）和谷丙转氨酶（GPT）活性增加。文中讨论了与强直性肌营养不良发病机制相关的可能解释。