豚鼠体内组织抗原诱导的巨噬细胞游走抑制
Macrophage migration inhibition induced by tissue antigen in guinea-pigs.
作者信息
Weir D M, Suckling E J
出版信息
Clin Exp Immunol. 1971 May;8(5):791-9.
Macrophage migration inhibition has been induced with cultures of normal guinea-pig peritoneal exudate cells and mitochondrial antigen of guinea-pig liver. The effect, like the antigen induced phenomenon, is prevented by exposure to trypsin. Puromycin and cycloheximide in contrast did not prevent macrophage migration inhibition. The migration inhibition was compared with the results of skin tests and with passive haemagglutination and immunocyto-adherence tests using liver antigen coated cells. Only the latter test was positive. The migration inhibitory effect is considered in relation to cell-mediated immunity to tissue antigens and its possible role in localization of macrophages in the inflammatory response.
用正常豚鼠腹腔渗出细胞培养物和豚鼠肝线粒体抗原诱导了巨噬细胞迁移抑制。与抗原诱导现象一样，该效应可通过胰蛋白酶处理而被阻止。相比之下，嘌呤霉素和环己酰亚胺并不能阻止巨噬细胞迁移抑制。将迁移抑制结果与皮肤试验结果以及使用肝抗原包被细胞的被动血凝试验和免疫细胞黏附试验结果进行了比较。只有后者试验呈阳性。结合对组织抗原的细胞介导免疫及其在炎症反应中巨噬细胞定位的可能作用，对迁移抑制效应进行了探讨。
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