扩展青霉产展青霉素和桔霉素及其生物活性
Produciton and biological activity of patulin and citrinin from Penicillium expansum.
作者信息
Ciegler A, Vesonder R F, Jackson L K
出版信息
Appl Environ Microbiol. 1977 Apr;33(4):1004-6. doi: 10.1128/aem.33.4.1004-1006.1977.
Abstract
Penicillium expansum isolated from meat and apples produced both patulin and citrinin. Toxin identity was confirmed by spectroscopic and physical methods. The mean lethal dose in chicken embryos was determined for toxins administered both singly and in various ratios. Data from simultaneous administration of mycotoxin combinations plotted as isobolograms showed and additive effect. Both toxins were teratogenic in chicken embryos.
摘要
从肉类和苹果中分离出的扩展青霉可产生展青霉素和桔霉素。通过光谱和物理方法确认了毒素的特性。测定了单独以及以不同比例施用毒素时在鸡胚中的平均致死剂量。将同时施用霉菌毒素组合的数据绘制成等效线图，结果显示为相加作用。两种毒素在鸡胚中均具有致畸性。
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