Pang L S, Morson B C
J Clin Pathol. 1967 Mar;20(2):128-35. doi: 10.1136/jcp.20.2.128.
The pathology and results of treatment of 36 cases of basaloid carcinomas of the anal canal are described. This variant of squamous cell carcinoma of the anal region arises from the entodermal-ectodermal junctional zone of the anal canal at or above the dentate line. Basaloid carcinomas have histological characteristics which resemble basal cell carcinoma of the skin, in particular the presence of palisading of the nuclei at the periphery of the clumps of tumour cells, but are potentially metastasizing tumours. They have been subdivided into three grades of malignancy, namely, well-differentiated, moderately differentiated, and anaplastic basaloid carcinoma. It has been shown that cases of well-differentiated and moderately differentiated basaloids have a good prognosis even when lymph node metastasis has already taken place. Those of anaplastic basaloid carcinoma have a very poor prognosis even in the absence of lymphatic metastases.
本文描述了36例肛管基底样癌的病理及治疗结果。这种肛管区域鳞状细胞癌的变体起源于齿状线或其上方肛管的内胚层 - 外胚层交界区。基底样癌具有类似于皮肤基底细胞癌的组织学特征，特别是肿瘤细胞团块周边核呈栅栏状排列，但它们是具有潜在转移能力的肿瘤。它们已被细分为三个恶性等级，即高分化、中分化和间变性基底样癌。研究表明，高分化和中分化基底样癌病例即使已经发生淋巴结转移，预后也较好。间变性基底样癌病例即使没有淋巴转移，预后也非常差。
