Herz F, Miller O J, Miller D A, Auersperg N, Koss L G
Cancer Res. 1977 Sep;37(9):3209-13.
The C41 cell line, which was derived from a human squamous carcinoma of the uterine cervix, has been characterized by analysis of quinacrine-banded metaphase chromosomes and study of alkaline phosphatase. C41 cells have a distinctive karyotype. They are hypodiploid, with a highly characteristic series of marker chromosomes, most of them derived by translocation or deletion. They contain no HeLa cell marker chromosomes, and the cell line shows no evidence of HeLa cell contamination. Nevertheless, the C41 and the HeLa cell line, both derived from cervix cancer, although of a different histological type, produce similar alkaline phosphatases. The enzyme is heat stable (placental type), is inhibited by L-phenylalanine, and responds to the inducing effects of prednisolone and/or hyperosmolality.
C41细胞系源自人子宫颈鳞状癌，已通过对喹吖因带型中期染色体的分析和碱性磷酸酶研究进行了表征。C41细胞具有独特的核型。它们是亚二倍体，具有一系列高度特征性的标记染色体，其中大多数是通过易位或缺失产生的。它们不含HeLa细胞标记染色体，且该细胞系没有HeLa细胞污染的迹象。然而，C41细胞系和HeLa细胞系均源自宫颈癌，尽管组织学类型不同，但产生相似的碱性磷酸酶。该酶具有热稳定性（胎盘型），受L-苯丙氨酸抑制，并对泼尼松龙和/或高渗的诱导作用有反应。
