镰状细胞视网膜病变中新血管形成的演变。一项前瞻性荧光素血管造影研究。

Evolution of neovascularization in sickle cell retinopathy. A prospective fluorescein angiographic study.

作者信息

Raichand M, Goldberg M F, Nagpal K C, Goldbaum M H, Asdourian G K

出版信息

Arch Ophthalmol. 1977 Sep;95(9):1543-52. doi: 10.1001/archopht.1977.04450090065005.

DOI:10.1001/archopht.1977.04450090065005

Abstract

With prospective observations we have documented by fluorescein angiography the development of retinal neovascularization in the eyes of patients with sickle cell-hemoglobin C disease (hemoglobin SC). In each patient, arteriolarvenular (AV) anastomoses occurred before the development of neovascular sea fans. To our knowledge, this report constitutes the first such documentation in the literature. New sea fans from AV anastomoses appeared throughout an average interval of 18 months (range, 8 to 36 months) in approximately 21% of young adults with hemoglobin SC. Each year approximately 14% of young patients with hemoglobin SC may develop retinal neovascularization.

摘要

通过前瞻性观察，我们利用荧光素血管造影记录了镰状细胞-血红蛋白C病（血红蛋白SC）患者眼部视网膜新生血管的发展情况。在每位患者中，动静脉（AV）吻合在新生血管海扇形成之前就已出现。据我们所知，本报告是文献中首次对此类情况的记录。来自AV吻合的新海扇在大约21%的血红蛋白SC年轻成年人中平均间隔18个月（范围为8至36个月）出现。每年约14%的血红蛋白SC年轻患者可能会发生视网膜新生血管。