Barlogie B, Drewinko B, Schumann J, Freireich E J
Cancer Res. 1976 Mar;36(3):1182-7.
The kinetic response of a human lymphoma cell line to bleomycin has been analyzed, using an ICP-11 pulse cytophotometer. Bleomycin induced a delay of the cell-cycle traverse in G2 phase, the extent and recovery of which depended on drug concentration, exposure time, and cell cycle stage where treatment was applied. Different phase sensitivity for lethal damage (G2 phase) and kinetic response (early S phase) were documented. Recovery from G2 block did not predict for unimpaired reproductive capacity.
利用ICP-11脉冲细胞光度计分析了人淋巴瘤细胞系对博来霉素的动力学反应。博来霉素诱导细胞周期在G2期的进程延迟，其延迟程度和恢复情况取决于药物浓度、暴露时间以及施加处理时的细胞周期阶段。记录了对致死性损伤（G2期）和动力学反应（S期早期）的不同阶段敏感性。从G2期阻滞中恢复并不能预测生殖能力未受损。
