γ射线和紫外线辐射引起的DNA性质变化。构象变化对损伤化学性质的依赖性。
Changes in properties of DNA caused by gamma and ultraviolet radiation. Dependence of conformational changes on the chemical nature of the damage.
作者信息
Vorlícková M, Palecek E
出版信息
Biochim Biophys Acta. 1978 Feb 16;517(2):308-18.
PMID:564206
Abstract
Changes in the pulse-polarographic behaviour and circular dichroism spectra of DNA were investigated after gamma and ultraviolet irradiations and after degradation by DNAse I. It was found that moderate doses of radiation cause local conformational changes in the double helix, which are dependent on the chemical nature of the damage. Only the accumulation of structural changes after high doses of the radiations or after extensive enzymic treatment may cause formation of single-stranded regions in DNA.
摘要
研究了γ射线和紫外线照射以及DNA酶I降解后DNA的脉冲极谱行为和圆二色光谱的变化。发现中等剂量的辐射会导致双螺旋结构发生局部构象变化，这种变化取决于损伤的化学性质。只有高剂量辐射或广泛酶处理后结构变化的积累才可能导致DNA中形成单链区域。
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