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γ射线和紫外线辐射引起的DNA性质变化。构象变化对损伤化学性质的依赖性。

Changes in properties of DNA caused by gamma and ultraviolet radiation. Dependence of conformational changes on the chemical nature of the damage.

作者信息

Vorlícková M, Palecek E

出版信息

Biochim Biophys Acta. 1978 Feb 16;517(2):308-18.

PMID:564206
Abstract

Changes in the pulse-polarographic behaviour and circular dichroism spectra of DNA were investigated after gamma and ultraviolet irradiations and after degradation by DNAse I. It was found that moderate doses of radiation cause local conformational changes in the double helix, which are dependent on the chemical nature of the damage. Only the accumulation of structural changes after high doses of the radiations or after extensive enzymic treatment may cause formation of single-stranded regions in DNA.

摘要

研究了γ射线和紫外线照射以及DNA酶I降解后DNA的脉冲极谱行为和圆二色光谱的变化。发现中等剂量的辐射会导致双螺旋结构发生局部构象变化，这种变化取决于损伤的化学性质。只有高剂量辐射或广泛酶处理后结构变化的积累才可能导致DNA中形成单链区域。

相似文献

1
Changes in properties of DNA caused by gamma and ultraviolet radiation. Dependence of conformational changes on the chemical nature of the damage.γ射线和紫外线辐射引起的DNA性质变化。构象变化对损伤化学性质的依赖性。
Biochim Biophys Acta. 1978 Feb 16;517(2):308-18.
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引用本文的文献

1
An electrochemical analysis of changes in properties of DNA caused by ionizing and ultraviolet radiations.
Radiat Environ Biophys. 1980 Feb;17(2):129-41. doi: 10.1007/BF02027849.
2
Structural alterations of pathologically or physiologically modified DNA.病理或生理修饰的DNA的结构改变。
Nucleic Acids Res. 1984 Feb 24;12(4):1977-89. doi: 10.1093/nar/12.4.1977.
3
Inhibition of Micrococcus luteus DNA topoisomerase I by UV photoproducts.紫外线光产物对藤黄微球菌DNA拓扑异构酶I的抑制作用。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1787-91. doi: 10.1073/pnas.80.7.1787.
4
Structural defects in rat liver deoxyribonucleic acid. Endogenous single-strained regions in comparison with damage induced in vivo by a carcinogen.大鼠肝脏脱氧核糖核酸的结构缺陷。内源性单链区域与致癌物在体内诱导的损伤的比较。
Biochem J. 1979 May 1;179(2):341-52. doi: 10.1042/bj1790341.
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Changes in the circular dichroic spectrum of calf thymus solubilized chromatin caused by ultraviolet irradiation.紫外线照射引起的小牛胸腺可溶染色质圆二色光谱的变化。
Radiat Environ Biophys. 1979 Apr 30;16(2):117-23. doi: 10.1007/BF01323219.
6
Endonuclease alpha from Saccharomyces cerevisiae shows increased activity on ultraviolet irradiated native DNA.来自酿酒酵母的核酸内切酶α对紫外线照射的天然DNA表现出更高的活性。
Mol Gen Genet. 1978 Nov 29;167(2):139-45. doi: 10.1007/BF00266907.