甲状腺髓样癌淀粉样纤维蛋白的特性分析
Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid.
作者信息
Sletten K, Westermark P, Natvig J B
出版信息
J Exp Med. 1976 Apr 1;143(4):993-8. doi: 10.1084/jem.143.4.993.
Abstract
Amyloid fibrils were studied from two different tissues of medullary carcinoma of the thyroid (MCT). The fibrils mainly consisted of a low molecular weight protein, AMCT, which was immunologically distinct and did not react with various antisera against known amyloid fibril proteins. A specific antiserum raised against the MCT amyloid proteins gave a reaction of identity with the degraded MCT amyloid fibrils from two patients, as well as with the isolated AMCT protein, but showed no reaction with other known amyloid proteins. The AMCT protein had a blocked N terminus, but the sequence analysis of a cyanogen bromide fragment revealed identity with human calcitonin in the 11 positions studied. Although the amino acid composition was similar, there were also distinct differences, and the mol wt of 5,700 daltons was considerably larger than that of calcitonin. For these reasons the AMCT protein may represent a prohormone of calcitonin.
摘要
对甲状腺髓样癌（MCT）的两种不同组织中的淀粉样原纤维进行了研究。这些原纤维主要由一种低分子量蛋白质AMCT组成，该蛋白质在免疫上具有独特性，且不与针对已知淀粉样原纤维蛋白的各种抗血清发生反应。针对MCT淀粉样蛋白产生的特异性抗血清与两名患者降解后的MCT淀粉样原纤维以及分离出的AMCT蛋白呈现同一性反应，但与其他已知淀粉样蛋白无反应。AMCT蛋白的N端被封闭，但对溴化氰片段的序列分析显示，在所研究的11个位置上与人降钙素相同。尽管氨基酸组成相似，但也存在明显差异，且5700道尔顿的分子量比降钙素大得多。基于这些原因，AMCT蛋白可能代表降钙素的一种前激素。
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