在易患自身免疫性疾病的小鼠品系中，随着年龄增长，细胞免疫在体外逐渐丧失。
Progressive loss in vitro of cellular immunity with ageing in strains of mice susceptible to autoimmune disease.
作者信息
Rodey G E, Good R A, Yunis E J
出版信息
Clin Exp Immunol. 1971 Sep;9(3):305-11.
Abstract
The influence of ageing on the responses of mouse spleen cells to phytohaemagglutinin and to allogeneic cells was studied in NZB, (NZB×A)F, A and CBA mice. These responses decline with ageing in those strains which are genetically susceptible to autoimmune disease (NZB, (NZB×A)F and A) but not in a non-susceptible strain (CBA). These studies support the view that cellular immunity declines with advancing age in autoimmune-susceptible mice, and suggests that the decline is due to a progressive loss of the thymus-dependent cell pool.
摘要
在新西兰黑鼠（NZB）、（NZB×A）F1、A系和CBA小鼠中研究了衰老对小鼠脾细胞对植物血凝素和同种异体细胞反应的影响。在那些对自身免疫性疾病具有遗传易感性的品系（NZB、（NZB×A）F1和A系）中，这些反应随衰老而下降，但在非易感品系（CBA）中则不然。这些研究支持了这样一种观点，即在自身免疫易感小鼠中，细胞免疫随着年龄的增长而下降，并表明这种下降是由于胸腺依赖性细胞库的逐渐丧失所致。
相似文献
1
Progressive loss in vitro of cellular immunity with ageing in strains of mice susceptible to autoimmune disease.在易患自身免疫性疾病的小鼠品系中，随着年龄增长，细胞免疫在体外逐渐丧失。
Clin Exp Immunol. 1971 Sep;9(3):305-11.
2
3
Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.淋巴细胞活化。I. T淋巴细胞和B淋巴细胞对植物有丝分裂原的反应。
Clin Exp Immunol. 1971 Oct;9(4):483-98.
4
5
Ontogenesis of the in vitro response of murine lymphoid cells to cellular antigens and phytomitogens.小鼠淋巴细胞对细胞抗原和植物有丝分裂原的体外反应的个体发生
J Immunol. 1972 Sep;109(3):534-9.
6
The effect of Leishmania tropica on stimulation of lymphocytes with phytohaemagglutinin.热带利什曼原虫对用植物血凝素刺激淋巴细胞的影响。
Immunology. 1976 May;30(5):629-34.
7
Studies on in vitro models of cellular immunity.细胞免疫的体外模型研究。
J Reticuloendothel Soc. 1971 Jul;10(1):28-49.
8
Phytohemagglutinin reactivity of lymphoid cells in aging neonatally thymectomized rats.
Transplantation. 1972 Sep;14(3):321-4.
9
[Immunologic aspects of lymphogranulomatosis].[淋巴肉芽肿病的免疫学方面]
Ter Arkh. 1972 May;44(5):10-6.
10
Indirect migration inhibition test in xenogeneic systems. 3. Cellular immunity to kidney grafts.异种系统中的间接迁移抑制试验。3. 对肾移植的细胞免疫。
Arch Immunol Ther Exp (Warsz). 1971;19(3):377-80.
引用本文的文献
1
Autoantibodies to a regulatory T cell subset in human ageing.人类衰老过程中针对调节性T细胞亚群的自身抗体。
Clin Exp Immunol. 1981 Aug;45(2):308-15.
2
Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans.年轻和老年人体内淋巴细胞亚群的自然杀伤及抗体依赖性细胞毒性作用
J Clin Immunol. 1981 Jul;1(3):141-8. doi: 10.1007/BF00922755.
3
Changes in human T lymphocytes after thymectomy and during senescence.胸腺切除术后及衰老过程中人类T淋巴细胞的变化。
J Clin Immunol. 1982 Oct;2(4):289-95. doi: 10.1007/BF00915069.
4
Characterization of immunoregulatory T lymphocytes during ageing by monoclonal antibodies.利用单克隆抗体对衰老过程中的免疫调节性T淋巴细胞进行表征。
Clin Exp Immunol. 1982 Apr;48(1):148-54.
5
Effect of development and aging on the response of canine lymphocytes to phytohemagglutinin.发育和衰老对犬淋巴细胞对植物血凝素反应的影响。
Infect Immun. 1974 Oct;10(4):695-9. doi: 10.1128/iai.10.4.695-699.1974.
6
Thymosin corrects the abnormal DNA synthetic response of NZB mouse thymocytes.胸腺素可纠正新西兰黑小鼠胸腺细胞异常的DNA合成反应。
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2637-41. doi: 10.1073/pnas.71.7.2637.
7
Alteration in DNA synthetic response of thymocytes from NZB mice of different ages.不同年龄NZB小鼠胸腺细胞DNA合成反应的改变。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3769-72. doi: 10.1073/pnas.70.12.3769.
8
Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.胸腺产物的研究。IV. 成年NZB和（NZB×NZW）F1小鼠血清中不存在“胸腺活性”
Clin Exp Immunol. 1973 Jun;14(2):247-56.
9
Natural cytotoxic autoantibody against thymocytes in NZB mice.针对NZB小鼠胸腺细胞的天然细胞毒性自身抗体。
Clin Exp Immunol. 1972 Sep;12(1):133-52.
10
Spontaneous delayed hypersensitivity to DNA in NZB mice.NZB小鼠对DNA的自发性迟发型超敏反应。
Immunology. 1974 Aug;27(2):241-4.
本文引用的文献
1
SPONTANEOUS AUTOIMMUNITY IN MICE: ANTIBODIES TO NUCLEOPROTEIN IN STRAIN A-J.小鼠的自发性自身免疫：A-J品系中针对核蛋白的抗体
Science. 1964 Mar 20;143(3612):1333-4.
2
Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice.NZB/BL小鼠的免疫病理学。VI. 可从脾脏分离出且对瑞士小鼠致病的病毒。
J Exp Med. 1967 Jul 1;126(1):53-62. doi: 10.1084/jem.126.1.53.
3
Response of NZB mice to foreign antigen and development of autoimmune disease.新西兰黑鼠对外源抗原的反应及自身免疫性疾病的发展。
J Reticuloendothel Soc. 1969 Feb;6(1):78-93.
4
Strain differences in the immune response of mice. I. The neonatal response to sheep red cells.小鼠免疫反应中的品系差异。I. 对绵羊红细胞的新生反应。
Immunology. 1968 Jul;15(1):35-50.
5
Deficient immunologic functions of NZB mice.新西兰黑鼠的免疫功能缺陷。
Proc Soc Exp Biol Med. 1968 Apr;127(4):1204-7. doi: 10.3181/00379727-127-32910.
6
IgA deficiency, antigenic barriers, and autoimmunity.免疫球蛋白A缺乏、抗原屏障与自身免疫
Cell Immunol. 1970 Jul;1(2):147-9. doi: 10.1016/0008-8749(70)90001-8.
7
Response of NZB and NZB-NZW spleen cells to mitogenic agents.新西兰黑鼠（NZB）和新西兰黑鼠-新西兰白鼠（NZB-NZW）脾细胞对促有丝分裂剂的反应。
J Immunol. 1970 Apr;104(4):918-23.
8
The in vitro response to phytohemagglutinin of lyphoid cells from normal and neonatally thymectomized adult mice.正常成年小鼠和新生期胸腺切除成年小鼠的淋巴细胞对植物血凝素的体外反应。
Int Arch Allergy Appl Immunol. 1969;36(4):399-407. doi: 10.1159/000230760.
9
The appearance of immunological competence at an early age in New Zealand black mice.新西兰黑鼠在幼年时免疫能力的出现。
Clin Exp Immunol. 1968 Jun;3(5):375-83.
10
Depletion of long-lived lymphocytes in old New Zealand black mice.老龄新西兰黑鼠体内长寿淋巴细胞的耗竭
Clin Exp Immunol. 1970 Apr;6(4):457-72.
Zotero 插件