Atkins R C, Holdsworth S R, Glasgow E F, Matthews F E
Lancet. 1976 Apr 17;1(7964):830-2. doi: 10.1016/s0140-6736(76)90480-3.
Glomeruli from 18 "normal" patients and from 35 patients with glomerulonephritis have been maintained in tissue-culture and examined by time-lapse cinemicroscopy and electron microscopy. At least two distinct cell types with features of epithelial and mesangial cells emerge in the outgrowths from normal and non-crescentic glomeruli. 4 patients with rapidly progressive glomerulonephritis formed a distinct subgroup. Glomerular culture revealed that their crescents contained large numbers of macrophages. This suggests that, contrary to belief, the crescents in rapidly progressive glomerulonephritis consist of accumulated macrophages rather than proliferated epithelial cells.
来自18名“正常”患者和35名肾小球肾炎患者的肾小球已在组织培养中保存，并通过延时电影显微镜和电子显微镜进行检查。在正常和非新月形肾小球的生长物中出现了至少两种具有上皮细胞和系膜细胞特征的不同细胞类型。4例快速进行性肾小球肾炎患者形成了一个独特的亚组。肾小球培养显示，他们的新月体含有大量巨噬细胞。这表明，与以往观点相反，快速进行性肾小球肾炎中的新月体是由积累的巨噬细胞而非增殖的上皮细胞组成。
