Fox J E, Bourdages R, Beck I T
Am J Dig Dis. 1978 Mar;23(3):193-200. doi: 10.1007/BF01072317.
We studied the effect of ethanol on glucose and water absorption in vivo. In preliminary experiments, using sodium amytal anesthesia, we found that control animals, whose jejunal segment was perfused without ethanol, required more anesthetic agent than those perfused with ethanol. Thus, to allow for unbiased comparison of the absorption data between the two groups of animals, all absorption studies were carried out on conscious restrained hamsters. We found that ethanol did not influence the permeability of the jejunum to polyethylene glycol (PEG) and meglumine diatrizoate. In addition, ethanol did not influence the time required for the onset of steady-state absorption. Using both the gravimetric and the electrical methods, we were unable to show any measurable osmotic pressure exerted by ethanol (150-1050 mM) on the hamster jejunum. In the absorption studies we found that perfusion of the hamster jejunum with five increasing concentration of ethanol (450-1050 mM) appeared to cause a concentration-dependent depression in steady-state glucose transport. Water transport was depressed only when 4.8% (1050 mM) ethanol was perfused.
我们研究了乙醇对体内葡萄糖和水吸收的影响。在初步实验中，使用戊巴比妥钠麻醉，我们发现空肠段未灌注乙醇的对照动物比灌注乙醇的动物需要更多的麻醉剂。因此，为了对两组动物的吸收数据进行无偏比较，所有吸收研究均在清醒受限的仓鼠身上进行。我们发现乙醇不影响空肠对聚乙二醇（PEG）和泛影葡胺的通透性。此外，乙醇不影响达到稳态吸收所需的时间。使用重量法和电学方法，我们均未能显示乙醇（150 - 1050 mM）对仓鼠空肠施加任何可测量的渗透压。在吸收研究中，我们发现用五种浓度递增的乙醇（450 - 1050 mM）灌注仓鼠空肠似乎会导致稳态葡萄糖转运呈浓度依赖性降低。仅当灌注4.8%（1050 mM）乙醇时，水转运才会降低。
