2,2'-联吡啶对豚鼠巨噬细胞释放C1Q的可逆性抑制作用：补体第一成分（C1）的一个亚组分C1Q生物合成中翻译后羟基化步骤的证据。 - Suppr

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超能文献

Reversible inhibition of C1Q release from guinea pig macrophages by 2,2'-dipyridyl: Evidence for a posttranslational hydroxylation step in the biosynthesis of C1Q, a subcomponent of the first component of complement (C1).

作者信息

Müller W, Hanauske-Abel H, Loos M

出版信息

FEBS Lett. 1978 Jun 15;90(2):218-22. doi: 10.1016/0014-5793(78)80372-x.

DOI:10.1016/0014-5793(78)80372-x

PMID:566678

Abstract

摘要

相似文献

Reversible inhibition of C1Q release from guinea pig macrophages by 2,2'-dipyridyl: Evidence for a posttranslational hydroxylation step in the biosynthesis of C1Q, a subcomponent of the first component of complement (C1).2,2'-联吡啶对豚鼠巨噬细胞释放C1Q的可逆性抑制作用：补体第一成分（C1）的一个亚组分C1Q生物合成中翻译后羟基化步骤的证据。

FEBS Lett. 1978 Jun 15;90(2):218-22. doi: 10.1016/0014-5793(78)80372-x.

Biosynthesis of the first component of complement by human and guinea pig peritoneal macrophages: evidence for an independent production of the C1 subunits.

J Immunol. 1978 Oct;121(4):1578-84.

Effects of inhibitors of C1q biosynthesis on macrophage Fc receptor subclass-mediated antibody-dependent cellular cytotoxicity and phagocytosis.C1q生物合成抑制剂对巨噬细胞Fc受体亚类介导的抗体依赖性细胞毒性和吞噬作用的影响。

Cell Immunol. 1987 Mar;105(1):127-35. doi: 10.1016/0008-8749(87)90062-1.

Evidence that C1q, a subcomponent of the first component of complement, is an Fc receptor of peritoneal and alveolar macrophages.补体第一成分的一个亚成分C1q是腹膜和肺泡巨噬细胞的Fc受体的证据。

Immunobiology. 1980 Apr;157(1):54-61. doi: 10.1016/S0171-2985(80)80062-3.

Inhibitors of C1q biosynthesis suppress activation of murine macrophages for both antibody-independent and antibody-dependent tumor cytotoxicity.C1q生物合成抑制剂可抑制鼠巨噬细胞的激活，从而抑制抗体非依赖型和抗体依赖型肿瘤细胞毒性。

J Immunol. 1990 Mar 15;144(6):2281-6.

Macrophage C1q: characterization of a membrane form of C1q and of multimers of C1q subunits.巨噬细胞C1q：C1q膜形式及C1q亚基多聚体的特性

J Immunol. 1987 Jun 1;138(11):3863-7.

Antibody-independent binding of the first component of complement (C1) and its subcomponent C1q to the S and R forms of Salmonella minnesota.补体第一成分（C1）及其亚成分C1q与明尼苏达沙门氏菌S型和R型的非抗体依赖性结合。

Infect Immun. 1981 Mar;31(3):1138-44. doi: 10.1128/iai.31.3.1138-1144.1981.

Inhibition of proline hydroxylation does not inhibit secretion of tropoelastin by chick aorta cells.脯氨酸羟化作用的抑制并不抑制鸡主动脉细胞对原弹性蛋白的分泌。

FEBS Lett. 1976 Jun 1;65(2):246-50. doi: 10.1016/0014-5793(76)80490-5.

Biosynthesis of normal and low-molecular-mass complement component C1q by cultured human monocytes and macrophages.培养的人单核细胞和巨噬细胞对正常和低分子量补体成分C1q的生物合成。

Biochem J. 1989 Jan 15;257(2):477-86. doi: 10.1042/bj2570477.

New cardiotonic agents: a search for digitalis substitute.

Life Sci. 1978;22(13-15):1139-47. doi: 10.1016/0024-3205(78)90083-8.

引用本文的文献

Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls.脯氨酰 4-羟化酶亚基 α1（P4HA1）是原发性黑素瘤预后不良的生物标志物，其耗竭可抑制黑素瘤细胞侵袭并破坏肿瘤血管壁。

Mol Oncol. 2020 Apr;14(4):742-762. doi: 10.1002/1878-0261.12649. Epub 2020 Feb 28.

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.补体 C1q 由胶原蛋白脯氨酰 4 羟化酶羟化，并且对稳定缺氧诱导因子的脯氨酰羟化酶结构域抑制剂的非靶标抑制敏感。

Kidney Int. 2017 Oct;92(4):900-908. doi: 10.1016/j.kint.2017.03.008. Epub 2017 May 12.

Modulation of mRNA expression and secretion of C1q in mouse macrophages by anti-inflammatory drugs and cAMP: evidence for the partial involvement of a pathway that includes cyclooxygenase, prostaglandin E2 and adenylate cyclase.抗炎药物和环磷酸腺苷对小鼠巨噬细胞中C1q的mRNA表达及分泌的调节：一条包括环氧化酶、前列腺素E2和腺苷酸环化酶的信号通路部分参与的证据

Immunology. 1995 Apr;84(4):638-44.

The relationship between collagen and C1q biosynthesis in cultured human fibroblasts.培养的人成纤维细胞中胶原蛋白与C1q生物合成之间的关系。

Biochem J. 1982 Aug 15;206(2):287-93. doi: 10.1042/bj2060287.

Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selectively suppress cellular hydroxyprolyl biosynthesis. Decrease in interstitial collagen and Clq secretion in cell culture.

Biochem J. 1987 Dec 15;248(3):625-33. doi: 10.1042/bj2480625.

Studies on enzymes of collagen biosynthesis and the synthesis of hydroxyproline in macrophages and mast cells.巨噬细胞和肥大细胞中胶原蛋白生物合成酶及羟脯氨酸合成的研究。

Biochem J. 1979 Aug 15;182(2):311-6. doi: 10.1042/bj1820311.

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