Wapnick A A, Lynch S R, Krawitz P, Seftel H C, Charlton R W, Bothwell T H
Br Med J. 1968 Sep 21;3(5620):704-7. doi: 10.1136/bmj.3.5620.704.
Studies of the ascorbic acid status in two subjects with idiopathic haemochromatosis and in 12 with transfusional siderosis showed that all had decreased levels of white cell ascorbic acid. The urinary excretion of ascorbic acid was also diminished in those subjects in whom such measurements were made. The administration of ascorbic acid was followed by only a small rise in the urinary ascorbic acid output, while the oxalic acid levels (measured in two subjects) showed a significant rise. These findings resemble those described in siderotic Bantu, and support the thesis that increased iron stores lead to irreversible oxidation of some of the available ascorbic acid.
对两名特发性血色素沉着症患者和12名输血性铁沉着症患者的抗坏血酸状态研究表明，所有人的白细胞抗坏血酸水平均降低。在进行了此类测量的患者中，抗坏血酸的尿排泄量也减少。给予抗坏血酸后，尿中抗坏血酸排出量仅略有增加，而（在两名患者中测量的）草酸水平则显著升高。这些发现与患铁沉着病的班图人所描述的情况相似，并支持铁储存增加会导致一些可用抗坏血酸不可逆氧化这一论点。
