通过胃泌素刺激胃酸分泌的活性来测定胃泌素。
Assay of gastrin by means of its gastric acid stimulating activity.
作者信息
Blair E L, Keenlyside R M, Newell D J, Reed J D, Richardson D D
出版信息
J Physiol. 1968 Oct;198(3):613-26. doi: 10.1113/jphysiol.1968.sp008629.
Abstract
- A method is described for the bio-assay of gastrin activity in the anaesthetized cat, based on the acid stimulating activity of gastrin.2. A ;gastrin' of unknown potency can be assayed in terms of a stable Standard Gastrin Extract or of Synthetic Human Gastrin I.3. The sensitivity of the method is such that it will detect quantities of Synthetic Human Gastrin I at least as small as those at present described as detectable by radioimmunological techniques.4. The precision of the assay is such that it falls in the category that has been described as very precise and well suited to clinical studies.
摘要
本文描述了一种基于胃泌素的酸刺激活性，在麻醉猫身上进行胃泌素活性生物测定的方法。
未知效价的“胃泌素”可以根据稳定的标准胃泌素提取物或合成人胃泌素I进行测定。
该方法的灵敏度足以检测到至少与目前放射免疫技术所描述的可检测量一样小的合成人胃泌素I的量。
该测定方法的精密度属于已被描述为非常精确且非常适合临床研究的类别。
相似文献
1
Assay of gastrin by means of its gastric acid stimulating activity.通过胃泌素刺激胃酸分泌的活性来测定胃泌素。
J Physiol. 1968 Oct;198(3):613-26. doi: 10.1113/jphysiol.1968.sp008629.
2
Factors affecting the bioassay of gastrin in the anesthetized rat.影响麻醉大鼠胃泌素生物测定的因素。
Arch Surg. 1970 Feb;100(2):205-9. doi: 10.1001/archsurg.1970.01340200093020.
3
Effects of isopropylnoradrenaline on tachyphylaxis of gastrin stimulated gastric acid secretion and mucosal blood flow in the anaesthetized cat.异丙肾上腺素对麻醉猫胃泌素刺激的胃酸分泌速发性耐受和黏膜血流的影响。
J Physiol. 1976 Jan;254(1):153-68. doi: 10.1113/jphysiol.1976.sp011226.
4
Gastrin activity in the chicken proventriculus.鸡前胃中的胃泌素活性。
Nature. 1973 Dec 14;246(5433):424-5. doi: 10.1038/246424a0.
5
Effect of gastrin I and caerulein on gastric acid secretion in rats.胃泌素I和蛙皮素对大鼠胃酸分泌的影响。
J Pharm Pharmacol. 1969 Jan;21(1):58-9. doi: 10.1111/j.2042-7158.1969.tb08134.x.
6
Mechanisms relating gastric acid secretion and mucosal blood flow during gastrin and histamine stimulation.胃泌素和组胺刺激期间胃酸分泌与黏膜血流的相关机制。
J Physiol. 1971 Dec;219(3):571-85. doi: 10.1113/jphysiol.1971.sp009678.
7
Investigation of gastrin activity in pancreatic islet tissue.胰岛组织中胃泌素活性的研究。
Acta Pathol Microbiol Scand. 1969;75(4):583-97.
8
Gastric acid and pepsin-stimulating activity of non-sulphated fragments of gastrin in the cat.胃泌素非硫酸化片段对猫胃酸和胃蛋白酶的刺激活性
Digestion. 1980;20(3):190-200. doi: 10.1159/000198439.
9
Biological and immunological properties of human gastrin I analogues.
Hoppe Seylers Z Physiol Chem. 1982 Jun;363(6):665-9.
10
Penultimate aspartyl unnecessary for stimulation of acid secretion by gastrin-related peptide.倒数第二个天冬氨酰对于胃泌素相关肽刺激胃酸分泌并非必需。
Nat New Biol. 1971 Dec 22;234(51):256. doi: 10.1038/newbio234256a0.
引用本文的文献
1
Comparison of gastrin bioactivity and immunoreactivity of antral extracts from man, pig and cat.人、猪和猫胃窦提取物中胃泌素生物活性与免疫反应性的比较。
J Physiol. 1982 Apr;325:419-21. doi: 10.1113/jphysiol.1982.sp014159.
2
The half-life of exogenous gastrin in the circulation.外源性胃泌素在循环中的半衰期。
J Physiol. 1970 Jun;208(2):299-315. doi: 10.1113/jphysiol.1970.sp009121.
3
Experiences with a rat bio-assay in the diagnosis of the Zollinger-Ellison syndrome.大鼠生物测定法在卓-艾综合征诊断中的应用经验。
Gut. 1970 May;11(5):409-19. doi: 10.1136/gut.11.5.409.
4
Peptide-secreting tumours with special reference to the pancreas.分泌肽类的肿瘤，特别提及胰腺。
Gut. 1969 Jul;10(7):506-15. doi: 10.1136/gut.10.7.506.
5
Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa.胰抑素，一种存在于回肠和结肠黏膜提取物中的胰腺分泌抑制剂。
J Physiol. 1979 Jul;292:455-67. doi: 10.1113/jphysiol.1979.sp012864.
本文引用的文献
1
STUDIES ON GASTRIN.胃泌素研究
Gut. 1964 Aug;5(4):327-41. doi: 10.1136/gut.5.4.327.
2
A method for biologic assay of gastrin.一种胃泌素的生物测定方法。
Gastroenterology. 1961 May;40:644-8.
3
Synthesis of human gastrin I.人胃泌素I的合成
Nature. 1966 Feb 5;209(5023):585-6. doi: 10.1038/209585a0.
4
Antibodies to the carboxyl-terminal tetrapeptide of gastrin.
Gastroenterology. 1967 Nov;53(5):697-705.
5
Antibodies to synthetic human gastrin I.
Lancet. 1967 Dec 2;2(7527):1180-2. doi: 10.1016/s0140-6736(67)91895-8.
Zotero 插件