软骨组织中的细胞分化与衰老过程。软骨细胞培养中的黏多糖合成。
Cellular differentiation and the aging process in cartilaginous tissues. Mucopolysaccharide synthesis in cell cultures of chondrocytes.
作者信息
Shulman H J, Meyer K
出版信息
J Exp Med. 1968 Dec 1;128(6):1353-62. doi: 10.1084/jem.128.6.1353.
Abstract
Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate. These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented.
摘要
已证实分化软骨细胞的原代细胞培养物产生硫酸软骨素-4作为主要的粘多糖，有迹象表明存在硫酸角质素以及可能的硫酸软骨素-6的合成。已表明鸡胚胎软骨主要由硫酸软骨素-4组成，含有少量硫酸软骨素-6，但基本不含硫酸角质素。将这些发现与其他人的数据进行了比较，并提出了一个从细胞分化角度解释软骨老化过程的假说。
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