Hayashi T T, Prinzo N, Hayashi J D
Am J Obstet Gynecol. 1978 Dec 1;132(7):766-74. doi: 10.1016/s0002-9378(78)80011-8.
Free and membrane-bound ribosomal ribonucleic acid (RNA) from maternal rat liver was measured in virgin rats and in variously dated pregnant animals that were either fed or starved for one to four days. The total amounts of free and membrane-bound ribosomal RNA differed between pregnant and nonpregnant rats, but the free ribosomal RNA progressively decreased only in the nonpregnant animals. A similar conservation of membrane-bound ribosomal RNA was observed with starvation among the pregnant rats except for the very early dated pregnant rats. Radioisotope labeling experiments using 3H-labeled orotic acid demonstrated a slower increase in specific activity among fed rats, irrespective of pregnancy state. However, metabolic and physiologic changes associated with pregnancy imposed additional complicating factors to the study.
在未交配的大鼠以及处于不同孕期、分别喂食或饥饿1至4天的怀孕动物中，测定了来自母鼠肝脏的游离核糖体核糖核酸（RNA）和膜结合核糖体核糖核酸。怀孕大鼠和未怀孕大鼠的游离核糖体RNA和膜结合核糖体RNA总量有所不同，但仅在未怀孕动物中游离核糖体RNA逐渐减少。除了极早期怀孕的大鼠外，在饥饿的怀孕大鼠中观察到膜结合核糖体RNA有类似的保存情况。使用3H标记乳清酸的放射性同位素标记实验表明，无论怀孕状态如何，喂食大鼠的比活性增加较慢。然而，与怀孕相关的代谢和生理变化给该研究带来了额外的复杂因素。
