药物治疗中的药代动力学。I：盐酸普萘洛尔作为辅助治疗甲状腺毒症。
Pharmacokinetics in drug therapy. I: Propranolol hydrochloride as adjunct therapy in the treatment of thyrotoxicosis.
作者信息
Robayo J R
出版信息
Am J Hosp Pharm. 1976 Feb;33(2):169-73.
PMID:56890
Abstract
A case study in which propranolol hydrochloride was used as adjunct therapy in the treatment of atrial fibrillation with rapid ventricular response, thyrotoxicosis and high output heart failure is presented to illustrate the pharmacokinetics of this drug. The relationship of propranolol dosage to blood levels, the effect of blood levels on pharmacological response, the metabolism and elimination of propranolol, and determination of rational dosage of the drug, are discussed.
摘要
本文介绍了一个病例研究，其中盐酸普萘洛尔被用作辅助治疗药物，用于治疗伴有快速心室反应的心房颤动、甲状腺毒症和高输出量心力衰竭，以说明该药物的药代动力学。文中讨论了普萘洛尔剂量与血药浓度的关系、血药浓度对药理反应的影响、普萘洛尔的代谢和消除，以及该药物合理剂量的确定。
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Pharmacokinetics in drug therapy. I: Propranolol hydrochloride as adjunct therapy in the treatment of thyrotoxicosis.药物治疗中的药代动力学。I：盐酸普萘洛尔作为辅助治疗甲状腺毒症。
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