关于铅和镉毒性中锌、铜和铁代谢相互作用的一些观察
Some observations on the interaction of zinc, copper, and iron metabolism in lead and cadmium toxicity.
作者信息
Petering H G
出版信息
Environ Health Perspect. 1978 Aug;25:141-5. doi: 10.1289/ehp.7825141.
Abstract
A brief review of the literature indicates that nutritional deficiencies have been shown to increase the absorption and toxicity of orally ingested lead and cadmium. Results from recent studies indicates that low level oral ingestion of cadmium and lead perturbs the metabolism of zinc, copper, and iron and that these changes may be the earliest manifestation of the toxicity of lead and cadmium. The significance of these findings reveals itself in two ways: namely, that toxicologic investigations of lead and cadmium, whether experimental or clinical, must be based on a definitive consideration of the nutritional status of animals or people, and, secondly, that the preventive role of nutrition, especially that of trace metal intakes, must be taken seriously when establishing measures for reducing, eliminating, or combatting the toxic effects of widespread exposure to lead and cadmium in humans.
摘要
对文献的简要回顾表明，营养缺乏已被证明会增加口服摄入铅和镉的吸收及毒性。近期研究结果表明，低水平口服镉和铅会扰乱锌、铜和铁的代谢，而这些变化可能是铅和镉毒性的最早表现。这些发现的重要性体现在两个方面：其一，对铅和镉的毒理学研究，无论是实验性的还是临床性的，都必须基于对动物或人类营养状况的明确考量；其二，在制定减少、消除或对抗人类广泛接触铅和镉的毒性影响的措施时，必须认真对待营养的预防作用，尤其是微量金属摄入的预防作用。
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本文引用的文献
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The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat.缺铁对大鼠摄入铅的组织含量及毒性的影响。
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