Dannaeus A, Johansson S G
Acta Paediatr Scand. 1979 May;68(3):377-82. doi: 10.1111/j.1651-2227.1979.tb05023.x.
47 infants with cow's milk sensitivity were followed for a period varying between 6 months to 4 years (mean 28 months). The age at onset of symptoms varied between 14 days to 20 months. The clinical course was studied in relation to reaginic allergy by use of serum IgE, skin prick test and RAST. Infants with an immediate onset of symptoms from the gastrointestinal tract and the skin after cow's milk intake were discerned as a distinct entity having a high frequency of atopy in the family, positive skin tests and positive RASTs to milk (71%). Cases with delayed reactions to cow's milk seldom had a positive RAST or skin test. Most infants of both groups showed an increasing tolerance to milk. In RAST positive infants the RAST-titers increased significantly after onset of symptoms. After having reached a peak the titers subclined in several cases. The titers did not reflect the degree of milk sensitivity during the follow-up period. However, infants who developed high titers seemed to develop tolerance more slowly than infants with low titers.
对47名对牛奶敏感的婴儿进行了为期6个月至4年（平均28个月）的随访。症状出现的年龄在14天至20个月之间。通过血清IgE、皮肤点刺试验和放射性变应原吸附试验（RAST）研究了与反应素性过敏相关的临床过程。摄入牛奶后胃肠道和皮肤立即出现症状的婴儿被视为一个独特的群体，其家族中特应性疾病的发生率很高，皮肤试验阳性，牛奶RAST试验阳性（71%）。对牛奶反应延迟的病例很少有RAST或皮肤试验阳性。两组中的大多数婴儿对牛奶的耐受性都有所增加。在RAST阳性的婴儿中，症状出现后RAST滴度显著升高。达到峰值后，在一些病例中滴度下降。在随访期间，滴度不能反映牛奶敏感程度。然而，RAST滴度高的婴儿似乎比滴度低的婴儿更慢地产生耐受性。
