利巴韦林对急性或持续性感染腮腺炎病毒的BHK - 21细胞的影响。
Effects of ribavirin on BHK-21 cells acutely or persistently infected with mumps virus.
作者信息
McCammon J R, Riesser V W
出版信息
Antimicrob Agents Chemother. 1979 Mar;15(3):356-60. doi: 10.1128/AAC.15.3.356.
Abstract
The effects of ribavirin on BHK-21 cells acutely infected with mumps virus were compared to the effects of the drug on the same cell line persistently infected with mumps virus. Visible cytotoxicity was minimal for both cell types; however, there was an inhibition of cell replication with increasing drug concentrations. Ribavirin had marked antiviral activity against both the acute and persistent infections as determined by an inhibition of hemadsorption plaque formation, decreased immunofluorescence, and a reduction in the release of infectious virus. Even after the drug had been on the persistently infected cells for 72 h, there was still antigen production detectable by immunofluorescence, although the cells no longer hemadsorbed chicken erythrocytes. Ribavirin removal from both types of infection resulted in the renewed synthesis of virus.
摘要
将利巴韦林对急性感染腮腺炎病毒的BHK - 21细胞的作用，与该药物对持续感染腮腺炎病毒的同一细胞系的作用进行了比较。两种细胞类型的可见细胞毒性均极小；然而，随着药物浓度增加，细胞复制受到抑制。通过抑制血细胞吸附斑形成、降低免疫荧光以及减少传染性病毒释放来确定，利巴韦林对急性感染和持续感染均具有显著的抗病毒活性。即使药物作用于持续感染的细胞达72小时后，仍可通过免疫荧光检测到抗原产生，尽管这些细胞不再吸附鸡红细胞。从两种感染类型中去除利巴韦林后，病毒会重新合成。
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