Mogenson G J, Wu M, Manchanda S K
Brain Res. 1979 Feb 2;161(2):311-9. doi: 10.1016/0006-8993(79)90072-6.
Ambulatory activity in rats was increased in a dose-related manner by microinjections of picrotoxin, a GABA antagonist, bilaterally into the ventral tegmental area. Microinjections of strychnine, a glycine antagonist, had no effect on activity. The ambulatory activity induced by microinjections of picrotoxin into the ventral tegmental area was significantly attenuated when the nucleus accumbens was pretreated with spiroperidol, a dopamine antagonist. These findings provide additional evidence that dopaminergic (A10) neurons projecting from the ventral tegmental area to the nucleus accumbens, contribute to locomotor activity. It is suggested that picrotoxin disinhibits the A10 dopaminergic neurons projecting to the nucleus accumbens.
通过向大鼠腹侧被盖区双侧微量注射γ-氨基丁酸（GABA）拮抗剂印防己毒素，大鼠的自主活动以剂量相关的方式增加。向大鼠腹侧被盖区双侧微量注射甘氨酸拮抗剂士的宁对活动没有影响。当伏隔核用多巴胺拮抗剂螺哌啶预处理后，向腹侧被盖区微量注射印防己毒素所诱导的自主活动显著减弱。这些发现提供了额外的证据，表明从腹侧被盖区投射到伏隔核的多巴胺能（A10）神经元有助于运动活动。有人提出，印防己毒素解除了对投射到伏隔核的A10多巴胺能神经元的抑制作用。
