Gaafar H, Mandour M, El-Ghazzawi E
ORL J Otorhinolaryngol Relat Spec. 1979;41(1):51-8. doi: 10.1159/000275434.
Nasal biopsies from 2 scleroma patients who had received previous X-ray therapy were investigated under the electron microscope. In the lamina propria, the majority of Mikulicz cells contained numerous small vacuoles. This was attributed to the effect of X-ray therapy causing temporary suppression of the inflammatory process followed by new granuloma formation. The vacuoles of the Mikulicz cells contained some fine granular and fibrillar material of unknown origin. Rounded electron-dense bodies with microprojections on their surface were present near some Mikulicz cells. These structures were considered to be Russell bodies. Occasional small lymph vessels with obstructed lumina were seen. This might indicate the rare spread of Klebsiella rhinoscleromatis bacilli to regional lymph nodes.
对2例曾接受过X线治疗的硬结病患者的鼻活检组织进行了电子显微镜检查。在固有层中，大多数米库利奇细胞含有大量小空泡。这归因于X线治疗的作用，导致炎症过程暂时受到抑制，随后形成新的肉芽肿。米库利奇细胞的空泡内含有一些来源不明的细颗粒和纤维状物质。在一些米库利奇细胞附近可见表面有微突起的圆形电子致密体。这些结构被认为是拉塞尔小体。偶尔可见管腔阻塞的小淋巴管。这可能表明鼻硬结克雷伯杆菌向区域淋巴结的罕见扩散。
