Papavasilious P S, Kutt H, Miller S T, Rosal V, Wang Y Y, Aronson R B
Neurology. 1979 Nov;29(11):1466-73. doi: 10.1212/wnl.29.11.1466.
We determined the concentrations of manganese in whole blood and hair in 52 epileptics, 6 blood relatives, and 24 normal controls. Blood, and possibly hair manganese content, was significantly lower in treated epileptics than in controls (p less than 0.002). Although not all patients showed reduced tissue manganese levels, most of those with frequent seizures had manganese levels falling below the lowest control level, suggesting a relationship between manganese tissue levels and high seizure activity. These differences in manganese levels were not correlated with the type, dose, or plasma levels of anticonvulsant medication. Reduced manganese availability at the neuronal level, where Mn++ stabilizes membrane excitability, may affect epileptogenic lesions to increase the likelihood of seizure activity.
我们测定了52名癫痫患者、6名血亲及24名正常对照者全血和头发中的锰浓度。接受治疗的癫痫患者的血液以及可能的头发锰含量显著低于对照组（p<0.002）。尽管并非所有患者的组织锰水平都降低，但大多数癫痫发作频繁的患者锰水平低于最低对照水平，提示锰组织水平与高癫痫发作活动之间存在关联。这些锰水平差异与抗惊厥药物的类型、剂量或血浆水平无关。在神经元水平，Mn++可稳定膜兴奋性，而锰的可用性降低可能会影响致痫性病变，增加癫痫发作活动的可能性。
