Pattillo R A, Gey G O, Delfs E, Mattingly R F
Science. 1968 Mar 29;159(3822):1467-9. doi: 10.1126/science.159.3822.1467.
A new in vitro hormone-synthesizing cell system, line BeWO, derived from human gestational choriocarcinoma, has been permanently established; a high degree of synthesis of functional hormone has been maintained for 18 months in tissue culture. Predominantly glycolytic metabolism, dependent on the level of glucose in the medium, has been observed. Many facets of placental and tumor-cell metabolism, growth, and differentiation are found in this unique multipotential cell.
一种新的体外激素合成细胞系——BeWO系已成功建立，它源自人妊娠滋养层细胞癌；在组织培养中，该细胞系已持续18个月维持高度的功能性激素合成。研究发现，其代谢主要为糖酵解代谢，且依赖于培养基中葡萄糖的水平。在这种独特的多潜能细胞中，可观察到胎盘和肿瘤细胞代谢、生长及分化的诸多方面。
