巨球蛋白结构：人免疫球蛋白μ和γ重链的同源性
Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.
作者信息
Wikler M, Köhler H, Shinoda T, Putnam F W
出版信息
Science. 1969 Jan 3;163(3862):75-8. doi: 10.1126/science.163.3862.75.
PMID:5763493
Abstract
The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human gammaM-globulin is homologous to the NH(2)-terminal sequences of the gamma-chain of human and rabbit gammaG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.
摘要
通过溴化氰裂解人γM球蛋白的μ链所获得的片段的氨基酸序列，与人及兔γG球蛋白γ链的NH₂末端序列同源，并且与人类轻链的序列相关。这支持了轻链和重链由共同祖先基因进化而来的假说。
Zotero 插件