Stimmel B, Goldberg J, Rotkopf E, Cohen M
JAMA. 1977 Mar 21;237(12):1216-20.
Three hundred thirty-five persons successfully detoxified from methadone hydrochloride maintenance were followed up for as long as six years to determine their ability to remain abstinent from narcotic use. At the end of the observation period, of the 269 persons located, 35% were narcotic-free, 58% had returned to narcotic use, and 8% were either jailed or deceased. The ability of a person to refrain from narcotic use was found to be highly associated with staff's assessment of progress and duration of methadone maintenance treatment. Relapse to narcotic use occurred regardless of length of abstinence, with 35% of relapses occurring after three or more years. While abstinence after narcotic dependency is possible, it is not a realistic goal for all. Premature detoxification from methadone maintenance is associated with a high recidivism rate to narcotics.
对335名成功从美沙酮维持治疗中脱毒的人员进行了长达六年的随访,以确定他们保持不使用麻醉药品的能力。在观察期结束时,在找到的269人中,35%无麻醉药品使用,58%恢复使用麻醉药品,8%入狱或死亡。发现一个人不使用麻醉药品的能力与工作人员对进展的评估和美沙酮维持治疗的持续时间高度相关。无论戒毒时间长短,都会出现复吸情况,35%的复吸发生在三年或更长时间之后。虽然麻醉药品依赖后有可能戒毒,但这并非对所有人都是现实的目标。美沙酮维持治疗过早脱毒与麻醉药品的高复发率相关。