Turkington R W, Hill R L
Science. 1969 Mar 28;163(3874):1458-60. doi: 10.1126/science.163.3874.1458.
Lactose synthesis in the mammary gland is dependent on the hormonally controlled synthesis of the two protein components of lactose synthetase, alpha-lactalbumin and a galactosyltransferase. Prolactin induces the synthesis of both proteins in mammary gland explants treated with insulin and hydrocortisone, but the induction kinetics cannot account for the asynchronous synthesis of the two proteins that are observed in vivo. Progesterone appears to take part in the control of lactose synthesis and acts to repress the formation of alpha-lactalbumin throughout pregnancy. At parturition, when the concentration of progesterone in the plasma decreases, the rate of alpha-lactalbumin synthesis increases.
乳腺中的乳糖合成依赖于乳糖合酶两种蛋白质成分（α-乳白蛋白和半乳糖基转移酶）受激素调控的合成。催乳素可诱导在胰岛素和氢化可的松处理的乳腺外植体中合成这两种蛋白质，但诱导动力学无法解释在体内观察到的这两种蛋白质的异步合成。孕酮似乎参与乳糖合成的调控，并在整个孕期抑制α-乳白蛋白的形成。在分娩时，当血浆中孕酮浓度降低时，α-乳白蛋白的合成速率增加。
