球形红假单胞菌中δ-氨基乙酰丙酸合成酶活性的调控
Control of delta-aminolaevulate synthetase activity in Rhodopseudomonas spheroides.
作者信息
Marriott J, Neuberger A, Tait G H
出版信息
Biochem J. 1969 Feb;111(4):385-94. doi: 10.1042/bj1110385.
Abstract
- delta-Aminolaevulate synthetase from Rhodopseudomonas spheroides grown semi-anaerobically undergoes a spontaneous activation during the first hour after the disruption of cells when homogenates are stored at 4 degrees . 2. After cultures of R. spheroides growing semi-anaerobically are oxygenated no activation of delta-aminolaevulate synthetase occurs in cell extracts. Cessation of activation in extracts is almost complete 10min. after oxygenation of cells has begun. 3. A heat-stable fraction of low molecular weight from semi-anaerobic cells reactivates delta-aminolaevulate synthetase in extracts of oxygenated cells and appears to contain a compound responsible for the spontaneous activation. 4. A heat-stable fraction of low molecular weight from oxygenated cells inhibits the spontaneous activation in extracts of semi-anaerobic cells. 5. The effect of oxygen on the rate of bacteriochlorophyll synthesis in R. spheroides may be mediated through alterations in the concentrations of a low-molecular-weight activator and inhibitor of delta-aminolaevulate synthetase.
摘要
- 半厌氧培养的球形红假单胞菌中的δ-氨基乙酰丙酸合成酶，在细胞破碎后的匀浆于4℃储存的最初1小时内会发生自发激活。2. 半厌氧生长的球形红假单胞菌培养物经充氧后，细胞提取物中的δ-氨基乙酰丙酸合成酶不会发生激活。细胞开始充氧后10分钟，提取物中的激活停止几乎完全。3. 来自半厌氧细胞的低分子量热稳定组分可使充氧细胞提取物中的δ-氨基乙酰丙酸合成酶重新激活，且似乎含有一种负责自发激活的化合物。4. 来自充氧细胞的低分子量热稳定组分可抑制半厌氧细胞提取物中的自发激活。5. 氧气对球形红假单胞菌中细菌叶绿素合成速率的影响可能是通过改变δ-氨基乙酰丙酸合成酶的低分子量激活剂和抑制剂的浓度来介导的。
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