NZB/NZW小鼠皮肤中的免疫复合物。

Immune complexes in skin of NZB/NZW mice.

作者信息

Sommer V M, Rudofsky U H, Gabrielsen A E

出版信息

Clin Exp Immunol. 1975 Dec;22(3):461-7.

PMID:57841

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538443/

Abstract

Skin biopsies were performed on female (NZB X NZW)F1 mice (B/W) at ages ranging from 1 to 12 months. The control strain was the C57B1/6. Immunoglobulin G and beta 1C globulin deposition was sought using the indirect immunofluorescence method. Both globulins were detected consistently at the dermal-epidermal junction from the age of 6 months. The pattern of staining was granular, and progressed from focal deposition to confluent and diffuse involvement of the basement membrane at 9-10 months of age. No staining was observed in any of the C57B1/6 mice up to 14 months of age. These findings increase the resemblance of B/W disease to human systemic lupus erythematosus.

摘要

对1至12月龄的雌性（新西兰黑鼠×新西兰白鼠）F1小鼠（B/W）进行皮肤活检。对照品系为C57B1/6。采用间接免疫荧光法检测免疫球蛋白G和β1C球蛋白沉积。从6月龄起，在真皮-表皮交界处始终能检测到这两种球蛋白。染色模式为颗粒状，在9至10月龄时从局灶性沉积发展为基底膜的融合性和弥漫性累及。在14月龄之前，任何C57B1/6小鼠均未观察到染色。这些发现增加了B/W疾病与人类系统性红斑狼疮的相似性。

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本文引用的文献

1

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J Exp Med. 1950 Jan 1;91(1):1-13. doi: 10.1084/jem.91.1.1.

2

Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro.对水痘和带状疱疹病原体在体外繁殖进行的荧光抗体研究。

Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):789-94. doi: 10.3181/00379727-86-21235.

3

Histological and fine structural abnormalities in the livers of NZB/NZW F1 hybrid mice.NZB/NZW F1 杂交小鼠肝脏的组织学和精细结构异常

Br J Exp Pathol. 1969 Jun;50(3):250-6.

4

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Medicine (Baltimore). 1968 Jul;47(4):337-69. doi: 10.1097/00005792-196807000-00002.

5

Standardized nomenclature for inbred strains of mice: fifth listing.小鼠近交系标准化命名法：第五版名录

Cancer Res. 1972 Aug;32(8):1609-46.

6

Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity.小鼠自身免疫现象与肾脏疾病。胸腺切除、衰老及免疫能力衰退的作用。

Lab Invest. 1970 Feb;22(2):121-30.

7

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