多次输血的NZB/NZW小鼠的长期存活。
Prolonged survival of hypertransfused NZB/NZW mice.
作者信息
Gabrielsen A E, Olsen C T
出版信息
Immunology. 1977 Oct;33(4):449-52.
Abstract
(NZB X NZW)F1 hybrid female mice were transfused fortnightly with 1 ml of packed buffy-coat-poor syngeneic erythrocytes, beginning at 3--4 months of age, in an effort to suppress erythropoiesis selectively and perhaps limit availabiliity of DNA for immune complex formation. The mean increase in survival was about 8 weeks (P less than 0-05). Repeatedly phlebotomized donor female mice tended to sicken earlier and die at younger ages. This is initial support for the hypothesis that erythroblast DNA may be involved in this SLE-like disease.
摘要
（新西兰黑鼠×新西兰白鼠）F1 杂交雌性小鼠从 3 - 4 月龄开始，每两周输注 1 ml 去除富含白细胞层的同基因红细胞，以选择性抑制红细胞生成，并可能限制用于免疫复合物形成的 DNA 的可利用性。存活期平均延长约 8 周（P＜0.05）。反复进行放血的供体雌性小鼠往往更早发病且在更年轻的时候死亡。这初步支持了成红细胞 DNA 可能参与这种类系统性红斑狼疮疾病的假说。
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