Brody N I, Siskind G W
Immunology. 1972 Jan;22(1):75-85.
Antigenic competition between two haptenic determinants was studied. It was shown that antigenic competition was greater if a 1- or 2-week interval is imposed between injection of the two antigens. Preimmunization with one antigen or with the carrier protein to which one hapten is coupled will decrease the effect of antigenic competition on the antibody response to that antigen or hapten and bring about a greater degree of depression of the antibody response to the second haptenic determinant. Finally, antigenic competition does not occur if the two antigens are injected so as to drain into different groups of regional lymph nodes. This is true even if a 3- or 7-day time interval is imposed between injection of the two antigens. The results are interpreted as suggesting that competition occurs at the level of the antigen processing' or localizing' step in the immune response.
研究了两种半抗原决定簇之间的抗原竞争。结果表明，如果在注射两种抗原之间间隔1周或2周，抗原竞争会更强。用一种抗原或与一种半抗原偶联的载体蛋白进行预免疫，会降低抗原竞争对该抗原或半抗原抗体反应的影响，并导致对第二种半抗原决定簇的抗体反应出现更大程度的抑制。最后，如果将两种抗原注射到不同组的局部淋巴结引流区，则不会发生抗原竞争。即使在注射两种抗原之间间隔3天或7天，情况也是如此。这些结果被解释为表明竞争发生在免疫反应中抗原“加工”或“定位”步骤的水平上。
