Anderson M J, Bainbridge D R, Pattison J R, Heath R B
Infect Immun. 1977 Jan;15(1):239-44. doi: 10.1128/iai.15.1.239-244.1977.
The development of a cell-mediated immune response to Sendai virus infection in mice was examined by the use of a 51Cr release assay of cytotoxicity. A low level of "background cytotoxicity" to Sendai virus-infected L cells was found in the spleens of uninfected CBA mice. Spleen cells from Sendai-infected mice showed an elevated level of cytotoxicity against these target cells for a period of 5 weeks, commencing 4 days after infection of the mice. A more transient response was observed in the spleens of mice infected with a serologically distinct virus, the Kunz strain of influenza. This cross-reacting, cell-mediated immune response was intermediate between that observed in unsensitized and Sendai-sensitized spleen cells. The relevance of these cell-mediated immune responses to respiratory tract virus infections is discussed.
通过使用51Cr释放细胞毒性测定法，研究了小鼠对仙台病毒感染的细胞介导免疫反应的发展。在未感染的CBA小鼠脾脏中发现了对仙台病毒感染的L细胞的低水平“背景细胞毒性”。从感染仙台病毒的小鼠脾脏细胞在感染小鼠4天后开始，在5周的时间内对这些靶细胞表现出升高的细胞毒性水平。在用血清学上不同的病毒——流感病毒Kunz株感染的小鼠脾脏中观察到更短暂的反应。这种交叉反应的细胞介导免疫反应介于未致敏和仙台致敏的脾脏细胞中观察到的反应之间。讨论了这些细胞介导免疫反应与呼吸道病毒感染的相关性。
