Nilsson S E, Knave B, Persson H E
Acta Ophthalmol (Copenh). 1977 Dec;55(6):1007-26. doi: 10.1111/j.1755-3768.1977.tb05682.x.
The present investigation shows that the membrane properties of the sheep pigment epithelial cells were very rapidly and severely affected by sodium iodate, whereas the effects concerning the neuroretina were delayed. The c-wave of the ERG was immediately abolished and replaced by a cornea-negative potential, but the a- and b-waves were preserved for about 80-100 min. Ultrastructurally the plasma membranes (particularly the basal plasma membrane) of the pigment epithelial cells were destroyed or less distinct than normally. The cell organelles were swollen and ruptured. There were indications that the pigment epithelium could no longer participate in the receptor outer segment turnover. The photoreceptor cells were morphologically undamaged, and few or no signs of injury were observed in the inner layers of the retina. The effects upon the neuroretinal functions seen after 80-100 min, consisting of a reduction of alpha- and beta-wave amplitudes, were most likely caused by an inability of the pigment epithelium to maintain in the long run its metabolic and barrier properties. It appears that at an early stage after sodium iodate injection, the present preparation may be useful for the study of the effects on the neuroretina proper of drugs and other agents.
目前的研究表明，碘酸钠可非常迅速且严重地影响绵羊色素上皮细胞的膜特性，而对神经视网膜的影响则出现延迟。视网膜电图的c波立即消失，代之以角膜负电位，但a波和b波可保留约80 - 100分钟。超微结构上，色素上皮细胞的质膜（尤其是基底质膜）遭到破坏或不如正常情况下清晰。细胞器肿胀并破裂。有迹象表明色素上皮细胞不再能够参与受体外段的更新。光感受器细胞在形态上未受损，视网膜内层几乎未观察到损伤迹象或无损伤迹象。80 - 100分钟后所见的对神经视网膜功能的影响，包括α波和β波振幅降低，很可能是由于色素上皮细胞长期无法维持其代谢和屏障特性所致。看来在注射碘酸钠后的早期阶段，本制剂可能有助于研究药物和其他制剂对神经视网膜本身的影响。
