Economides F, Bruley-Rosset M, Mathé G
Recent Results Cancer Res. 1977(62):56-61. doi: 10.1007/978-3-642-81174-6_9.
A combined treatment modality imcorporating surgery plus BCG immunotherapy was administered to (C57Bl/6 X DBA/2)F1 mice grafted with EAkR lymphosarcoma. A single preoperative local or postoperative systemic BCG administration cured 20-30% of the animals, but did not prolong the survival time of these groups. Repeated s.c. injections of BCG resulted in a significant increase in survival time compared to the group submitted to surgery alone. In contrast, multiple i.v. injections of BCG before and after surgery were no more effective than surgery alone and were less effective than a single postsurgical i.v. injection in producing cures. We have concluded that for local BCG therapy, multiple injections before and after surgery are more effective than a single injection. However, for systemic therapy, multiple injections are less effective than a single injection applied postoperatively.
对移植了EAkR淋巴肉瘤的（C57Bl/6×DBA/2）F1小鼠采用手术加卡介苗免疫疗法的联合治疗方式。术前单次局部或术后全身给予卡介苗可治愈20% - 30%的动物，但并未延长这些组别的生存时间。与仅接受手术的组相比，重复皮下注射卡介苗可显著延长生存时间。相比之下，手术前后多次静脉注射卡介苗并不比单纯手术更有效，且在产生治愈效果方面比术后单次静脉注射效果更差。我们得出结论，对于局部卡介苗治疗，手术前后多次注射比单次注射更有效。然而，对于全身治疗，多次注射比术后单次注射效果更差。
