Ahlborg U G, Larsson K
Arch Toxicol. 1978 Feb 21;40(1):63-74. doi: 10.1007/BF00353280.
The three isomers of tetrachlorophenol were administrated intraperitoneally to rats and the urinary excretion products studied. Tetrachloro-p-hydroquinone was identified as a major metabolite of 2,3,5,6-tetrachlorophenol, constituting about 35% of the dose given. Trichloro-p-hydroquinone was identified as a minor metabolite of both 2,3,4,5- and 2,3,4,6-tetrachlorophenol. 2,3,5,6-tetrachlorophenol was eliminated within 24 h, 2,3,4,6-tetrachlorophenol within 48 h while only 60% of the given dose of 2,3,4,5-tetrachlorophenol could be recovered within 72 h. The acute toxicity of the tetrachlorophenols and tetrachloro-p-hydroquinone was studied in mice upon oral and intraperitoneal administration. 2,3,5,6-tetrachlorophenol (LD50p.o. 109 mg . kg-1) was the most toxic compound followed by 2,3,4,6- and 2,3.4,5-tetrachlorophenol (LD50p.o. 131 and 400 mg . kg-1, respectively). Tetrachloro-p-hydroquinone proved to have low oral toxicity (LD50p.o. 500 mg . kg-1) but was more toxic than the tetrachlorophenols when administered intraperitoneally. The oral LD50 for pentachlorophenol, under identical experimental conditions was found to be 74 mg . kg-1.
将四氯苯酚的三种异构体经腹腔注射给予大鼠，并对尿排泄产物进行研究。四氯对苯二酚被鉴定为2,3,5,6 - 四氯苯酚的主要代谢产物，约占给药剂量的35%。三氯对苯二酚被鉴定为2,3,4,5 - 四氯苯酚和2,3,4,6 - 四氯苯酚的次要代谢产物。2,3,5,6 - 四氯苯酚在24小时内消除，2,3,4,6 - 四氯苯酚在48小时内消除，而在72小时内仅能回收2,3,4,5 - 四氯苯酚给药剂量的60%。对小鼠经口和腹腔注射给予四氯苯酚和四氯对苯二酚，研究其急性毒性。2,3,5,6 - 四氯苯酚（经口半数致死量为109 mg·kg⁻¹）是毒性最强的化合物，其次是2,3,4,6 - 四氯苯酚和2,3,4,5 - 四氯苯酚（经口半数致死量分别为131和400 mg·kg⁻¹）。四氯对苯二酚经证明经口毒性较低（经口半数致死量为500 mg·kg⁻¹），但腹腔注射时比四氯苯酚毒性更大。在相同实验条件下，五氯苯酚的经口半数致死量为74 mg·kg⁻¹。
