Einig H, Mayer D
Arzneimittelforschung. 1978;28(3a):527-31.
Analytical methods of determination, investigations of stability and the behaviour of the substance in artificial gastric and intestinal fluids are the bases for the formulation of an oral preparation of 14-hydroxy-3beta-[4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift). The problems of developing a stable form, the maintenance of uniform content and the bioavailability are discussed.
14-羟基-3β-[4-O-甲基-α-L-鼠李糖基)氧基]-14β-蟾蜍-4,20,22-三烯内酯(美普罗西拉林,克利夫特)口服制剂的配方依据是该物质的分析测定方法、稳定性研究以及在人工胃液和肠液中的行为。文中讨论了开发稳定剂型、保持含量均匀性和生物利用度等问题。