多糖介质中的免疫反应。多糖增强了与各种大小抗原的沉淀素反应。
Immune reactions in polysaccharide media. Polysaccharide-enhanced precipitin reactions with antigens of various sizes.
作者信息
Hellsing K
出版信息
Biochem J. 1969 Aug;114(1):145-9. doi: 10.1042/bj1140145.
Abstract
The influence of the size of the antigen in the polysaccharide-enhanced precipitin reaction was investigated. The experiments were carried out by addition of homologous antigens of different molecular sizes (the monomer, dimer and trimer of serum albumin and the monomer and dimer of immunoglobulin G) to the same preparation of antibody in the absence and presence of dextran. Dextran decreased the solubility of the immune complexes to a larger extent when the antigen size increased. This is in accord with the view that the polysaccharide effect is due to steric exclusion.
摘要
研究了抗原大小对多糖增强沉淀素反应的影响。实验通过在不存在和存在葡聚糖的情况下，将不同分子大小的同源抗原（血清白蛋白的单体、二聚体和三聚体以及免疫球蛋白G的单体和二聚体）添加到同一抗体制剂中来进行。当抗原大小增加时，葡聚糖在更大程度上降低了免疫复合物的溶解度。这与多糖效应是由于空间排斥的观点一致。
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Immune reactions in polysaccharide media. Polysaccharide-enhanced precipitin reactions with antigens of various sizes.多糖介质中的免疫反应。多糖增强了与各种大小抗原的沉淀素反应。
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