注射到冈恩大鼠体内后两种主要胆红素光产物的胆汁排泄动力学。
Kinetics of biliary excretion of the main two bilirubin photoproducts after injection into Gunn rats.
作者信息
Onishi S, Kawade N, Itoh S, Isobe K, Sugiyama S, Hashimoto T, Narita H
出版信息
Biochem J. 1981 Jul 15;198(1):107-12. doi: 10.1042/bj1980107.
Abstract
The kinetics of biliary excretion of the main two photoproducts after injection into Gunn rats were examined. The photoproducts that are obtained from experiments in vitro consist of unknown pigment, photobilirubin IXa and a small amount of (ZZ)-bilirubin IXa. It was confirmed previously that the first two photoproducts are identical with the main two photoproducts obtained in vivo. In experiments on four animals, the average of total biliary recoveries of unknown pigment was 81.4%, and that of photobilirubin IXa in the bile estimated by the Sigma-minus method was 29.8 min and that for unknown pigment was 4.3 min. The rate of thermal reversion of photobilirubin IXa to (ZZ)-bilirubin IXa in the bile at 37 degrees C was very rapid, i.e. its half-life was 6.2 min.
摘要
对注射到冈恩大鼠体内后两种主要光产物的胆汁排泄动力学进行了研究。体外实验得到的光产物包括未知色素、光胆红素IXa和少量（ZZ）-胆红素IXa。先前已证实前两种光产物与体内获得的两种主要光产物相同。在对四只动物的实验中，未知色素的总胆汁回收率平均为81.4%，用西格玛减法估算胆汁中光胆红素IXa的半衰期为29.8分钟，未知色素的半衰期为4.3分钟。在37摄氏度时，胆汁中光胆红素IXa热转化为（ZZ）-胆红素IXa的速度非常快，即其半衰期为6.2分钟。
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