一名高胆红素血症新生儿血清中胆红素-IXα几何异构体的证实及黄疸光疗机制
Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.
作者信息
Onishi S, Isobe K, Itoh S, Kawade N, Sugiyama S
出版信息
Biochem J. 1980 Sep 15;190(3):533-6. doi: 10.1042/bj1900533.
Abstract
Photobilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant was demonstrated for the first time by reversed-phase high-pressure liquid chromatography. The concentrations increased significantly during phototherapy. Corresponding to these changes in the serum, biliary unconjugated bilirubin concentrations increased markedly but photobilirubin-IX alpha was not detected in the bile. Moreover, large amounts of 'unknown pigment' that are diazo-negative appeared in the bile during phototherapy.
摘要
首次通过反相高压液相色谱法在一名高胆红素血症新生儿的血清中证实了光胆红素-IXα。在光疗期间，其浓度显著增加。与血清中的这些变化相对应，胆汁中未结合胆红素的浓度显著增加，但在胆汁中未检测到光胆红素-IXα。此外，在光疗期间，胆汁中出现了大量重氮反应阴性的“未知色素”。
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