接受光疗的婴儿血液中的光异构化胆红素。
Photoisomerized bilirubin in blood from infants receiving phototherapy.
作者信息
Lamola A A, Blumberg W E, McClead R, Fanaroff A
出版信息
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1882-6. doi: 10.1073/pnas.78.3.1882.
Abstract
A pigment different from (Z,Z)bilirubin-IX alpha was detected by fluorometric methods in blood specimens from newborn infants undergoing blue-light therapy for unconjugated hyperbilirubinemia; it was not detected in specimens from infants not under therapy. The phototherapy-associated pigment has fluorescence, solubility, and photochemical properties that are identical to those exhibited by what are thought to be configurational (Z leads to E) isomers of bilirubin. It is concluded that isomerized bilirubin in the blood of neonates under phototherapy can reach as high as 15% of the total.
摘要
采用荧光法在接受蓝光治疗以缓解非结合性高胆红素血症的新生儿血液样本中检测到一种不同于（Z,Z）胆红素-IXα的色素；未接受治疗的婴儿样本中未检测到该色素。这种与光疗相关的色素具有荧光、溶解性和光化学性质，与被认为是胆红素构型（Z转化为E）异构体所表现出的性质相同。得出的结论是，接受光疗的新生儿血液中异构化胆红素可高达总量的15%。
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本文引用的文献
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Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.一名高胆红素血症新生儿血清中胆红素-IXα几何异构体的证实及黄疸光疗机制
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