Mansfield C M, Hartman G V, Reddy E K
J Natl Med Assoc. 1978 Feb;70(2):103-4.
Until recently, non-Hodgkin lymphoma has been difficult to understand. This was due to a lack of appreciation for histologic types, their sub-classifications, modes of spread, and sites of recurrence.The treatment of choice for stage I-II disease is radiation therapy. The value of irradiating adjacent uninvolved node areas or the more extensive Hodgkin-type mantle or inverted "Y" fields is uncertain.Most patients already have reached stage III or IV when first seen. Stage III cases should be treated by a combination of radiation therapy and chemotherapy. There are protocol studies evaluating the role of chemotherapy alone in stage III disease. The primary treatment of stage IV disease probably should be chemotherapy followed by radiation therapy to involved areas or to residual bulky disease.
直到最近，非霍奇金淋巴瘤仍难以理解。这是由于对组织学类型、亚分类、扩散方式及复发部位缺乏认识。I-II期疾病的首选治疗方法是放射治疗。对相邻未受累淋巴结区域或更广泛的霍奇金型斗篷野或倒“Y”野进行照射的价值尚不确定。大多数患者初诊时已处于III期或IV期。III期病例应采用放射治疗和化疗相结合的方法。有方案研究在评估单纯化疗在III期疾病中的作用。IV期疾病的主要治疗可能应是化疗，随后对受累区域或残留的大块病灶进行放射治疗。
